I haven't really thought about doing this type of a defense before, but I feel a sitelock + setaside defense could work.
Rough version I just made:
Cards in deck: 35
Lost Souls: 7
   Lost Soul (Color Guard)
   Lost Soul (deck discard)
   Lost Soul (Female Only)
   Lost Soul (N.T. only)
   Lost Soul (shame)
   Lost Soul (Site Discard)
   Lost Soul (Wanderer)
Fortresses: 2
   High Places
   Kingdoms of the World
White Sites: 1
   Mildewed House
Red Sites: 3
   Babylon
   Lion's Den
   Lion's Den
Green Sites: 1
   Babylonian Banquet Hall
Blue Sites: 1
   Hormah
Purple Sites: 1
   Pergamum
White Covenant Cards: 2
   Plagued with Diseases (Brown)
   Wastelands (Orange)
Crimson Evil Characters: 1
   Red Dragon
Brown Evil Characters: 5
   Haman
   King Ahaz
   King Jeroboam I
   King Nadab
   Persian Presidents
Multi-Color Evil Enhancements: 2
   Demonic Blockade (orange/brown)
   Two Possessed by Demons (Orange)
Crimson Evil Enhancements: 1
   Nebuchadnezzar's Pride
Brown Evil Enhancements: 5
   Image of Jealousy
   Siege
   Taking Naboth's Vineyard
   Threatened Lives
   Weakness
It seems a sitelock version of this would ONLY work in large defenses, which is what I'm used to. 
